Blood product transfusion is an important treatment for some hematological diseases, such as chronic aplastic anemia, myelodysplastic syndrome, etc. By transfusion of red blood cells and platelets, anemia can be corrected, and important organ bleeding caused by thrombocytopenia can be prevented, so as to improve or improve the quality of life of patients and prolong their survival time, but for a long time. Repeated repeated blood product transfusion during the period can result in invalid blood transfusion, which includes invalid red blood cell transfusion and invalid platelet transfusion. Invalid red blood cell transfusion is related to the total number of transfusions and the amount of previous transfusions. The more the number of transfusions, the greater the total amount of previous transfusions, the higher the incidence of invalid transfusions. The incidence of invalid transfusions of those who have transfused more than 10 times can sometimes reach more than 30%.
Non-immune factors include splenomegaly, fever, infection, hemorrhage, bone marrow transplantation, drug-related antibodies or toxins, platelet quality, etc. Immune factors include ABO blood group incompatibility, human leukocyte-related antigen. (HLA), platelet specific antigen (HPA) isoimmunization and autoantibodies. Corresponding prevention and treatment measures include: removing white blood cells, gamma-ray irradiation, intravenous immunoglobulin, platelet cross-matching, plasma exchange, the use of immunosuppressive agents, etc.
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