It was discovered in the 1950s that leukocytes present in blood sensitize transfusion recipients, resulting in Nonhemolytic FebrileTransfusion Reaction (NHFTR). Since then, allogeneic leukocytes in various blood components have been shown to be involved in a number of adverse responses in recipients.
The following table shows the relationship between the number of residual leukocytes and adverse reactions. Side effects can be avoided if residual leukocytes are reduced to around 1.0x106, which most researchers currently agree is the target.
Relationship between the number of residual leukocytes and adverse reactions
Filtration is the best method for leukocyte reduction.
Methods of leukocyte reduction include centrifugation, washing, freezing, buffy coat removal and filtration. Efficiency varies in each method.
DAJI Leukocyte Reduction Filter apply innovative and unique filtration technology combining interception and adsorption filtration to achieve the highest efficiency. Interception filters are usually composed of densely packed fibers to remove particles, condensates and micro-aggregates when they pass through the filter. Adsorption White Blood Cell Filter utilize the properties of white blood cells, which selectively adhere to filter fibers.
When is leukocyte reduced blood transfusion recommended?
Leukocyte-free blood transfusion is recommended in:
3Sickle cell anemia
6Patients awaiting organ transplantation
7Prevention of platelet refractoriness in thrombocytopenia
8Multiply or chronically transfused patients