In the field of blood transfusion, in addition to infusing a whole blood product obtained by adding an anticoagulant to blood collected from a blood donor to a recipient, separation and transfusion of blood components into the recipients have also been commonly used. According to the type of blood components required by the recipient, blood components transfusion means red blood cell transfusion, platelet transfusion, plasma transfusion, and the like. Blood products for transfusion of blood components include red blood cell products, platelet products, plasma products, and so on.
In recent years, leukocyte-free blood transfusion in which blood products are infused after removal of white blood cells from blood products has been widely used. This is because people have found relatively mild side effects associated with blood transfusion, such as headache, nausea, chills or a small number of non-hemolytic fever reactions, or severe side effects that severely affect recipients, such as alloantigen sensitization, viral infections, graft-versus-host disease (GVHD) after transfusion are mainly caused by white blood cells contained in blood products used for blood transfusion.
In recent years, leukocyte depletion therapy using extracorporeal blood circulation has been used to treat diseases such as rheumatism or ulcerative colitis, and excellent clinical results have been achieved.
The method for removing white blood cells from blood products is roughly classified into two kinds of centrifugation methods in which a centrifuge is used to separate and remove white blood cells using a difference in specific gravity between blood components, and a filtration method in which a non-woven fabric, for example, is used. The filter material of the fiber assembly having a porous structure of continuous pores or the like removes white blood cells. Currently the most widely used filtration method for removing leukocytes by adhesion and adsorption is because this method has the advantages of simple operation and low cost.
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